(CNN) -- In sweeping discipline that one analyst called "historic," New Orleans Saints Head Coach Sean Payton was suspended without pay for the entire 2012 season and former Saints defensive coach Gregg Williams was suspended indefinitely in a series of NFL punishments Wednesday for the team's bounty program against opponents.
Under the bounties, the team paid bonuses for knocking opposing players out of a game, the NFL said.
Saints General Manager Mickey Loomis was suspended without pay for the first eight regular-season games of the 2012 season, the NFL said. Assistant Head Coach Joe Vitt was suspended without pay for the first six regular-season games, the league said.
The team was also fined $500,000, and the team will forfeit its second-round draft picks in 2012 and 2013, the National Football League said.
NFL Commissioner Roger Goodell will review the status of Williams, now with the St. Louis Rams, at the end of the season and whether to reinstate him, the league said.
In issuing the punishments, Goodell described the Saints' violations of league rules "particularly unusual and egregious." He added that "a strong and lasting message must be sent."
Goodell said he is reviewing with the NFL Players Association discipline for players involved in the bounty program and he will address the matter at a later date.
One sports analyst, Jim Trotter of Sports Illustrated, said the discipline is "historic."
"One of the reasons they could be so strong against the Saints was that there was a paper trail," Trotter said, referring to e-mails.
"I don't think other teams would be dumb enough to put it in writing," Trotter said of the bounty system. "I definitely believe they are trying to make an example of them."
The NFL already is facing class-action lawsuits from former players of various teams who claimed that league play led to concussions, head trauma and chronic traumatic encephalopathy, a dementia-like brain disease.
"The league has to be concerned about lawsuits," Trotter said.
The NFL investigation found the Saints had an "active bounty program" during the 2009, 2010 and 2011 seasons in which "bounty" payments were paid for "knock-outs" and "cart-offs" -- plays in which an opposing player had to leave the game, the league said in a statement. The bounties even identified specific players as targets, the league said.
The investigation found that the Saints showed "a deliberate effort to conceal the program's existence from league investigators, and a clear determination to maintain the program despite express direction from Saints ownership that it stop as well as ongoing inquiries from the league office," the NFL said.
Goodell said the "pay-for-performance" program "undermined the integrity of the game."
The league found that Payton, as head coach, failed to supervise players and coaches, didn't inquire into the facts of the bounty program though he was aware of the league's inquiries, and encouraged "the false denials by instructing assistants to 'make sure our ducks are in a row,' " the NFL statement said.
Added Goodell: "When there is targeting of players for injury and cash rewards over a three-year period, the involvement of the coaching staff, and three years of denials and willful disrespect of the rules, a strong and lasting message must be sent that such conduct is totally unacceptable and has no place in the game.
"Beyond the clear and continuing violations of league rules, and lying to investigators, the bounty program is squarely contrary to the league's most important initiatives -- enhancing player health and safety and protecting the integrity of the game," the commissioner continued.
"Let me be clear. There is no place in the NFL for deliberately seeking to injure another player, let alone offering a reward for doing so," Goodell said.
On his Twitter account, Saints quarterback Drew Brees wrote: "I am speechless. Sean Payton is a great man, coach, and mentor. The best there is. I need to hear an explanation for this punishment."
Saints starting linebacker Jo-Lonn Dunbar also tweeted: "Can we all say #excessive".
At a press conference Wednesday afternoon, St. Louis Rams head coach Jeff Fisher said that the indefinite suspension of his defensive coordinator, Williams, didn't come as "a complete surprise."
But he said Williams was "surprised and shocked."
Fisher said the Rams had no idea when they hired Williams "that this would happen."
"He made a mistake and he admitted to that mistake and he's remorseful and he regrets the decision he has made and he has accepted the consequences," Fisher said of Williams.
On Wednesday, the NFL laid out a narrative of the Saints' bounty program.
Players regularly made cash "donations" to a pool and were also "fined" for mental errors, loafing, and penalties, the NFL probe found.
At least one assistant coach, Williams, also occasionally contributed to the pool, but the NFL found no evidence that any team money went to the fund.
Payments were made for plays in which opposing players were injured and for interceptions and fumble recoveries, the NFL said.
"The investigation showed bounties being placed on four quarterbacks of opposing teams -- Brett Favre, Cam Newton, Aaron Rodgers, and Kurt Warner," the NFL said.
Several players pledged money for bounties on specific opponents, "with defensive captain Jonathan Vilma offering $10,000 to any player who knocked Brett Favre out of the NFC Championship Game in 2010," the NFL said.
CNN's Tim Clark contributed to this report.